Article

Semi-automated [68Ga]Ga-FAPI-46 radiosynthesis using GalliAd® generator and MiniAIO® synthesizer: development and validation for PET imaging of fibroblast activation protein

2026-06-16

Abstract excerpt

<title>Abstract</title> <p> <bold>Background:</bold> Fibroblast activation protein (FAP) is a membrane-bound serine protease that is selectively overexpressed on cancer-associated fibroblasts (CAFs) in more than 90% of epithelial tumours. [68Ga]Ga labelled FAP inhibitors (FAPI) have emerged as promising PET tracers for oncological imaging and theranostic applications. [68Ga]Ga-FAPI-46 is a DOTA-chelated FAPI th...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 777589e9-6c9b-58cb-a28a-100a260ee64f
DOI: 10.21203/rs.3.rs-9927204/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Semi-automated [68Ga]Ga-FAPI-46 radiosynthesis using GalliAd® generator and MiniAIO® synthesizer: development and validation for PET imaging of fibroblast activation proteinDOI 10.21203/rs.3.rs-9927204/v1Read

GMP-Compliant Automated Radiolabeling and Quality Controls of [68Ga]Ga-FAPI-46 for Fibroblast Activation Protein-Targeted PET Imaging in Clinical SettingsSemantic proximity Read

Targeting fibroblast activation protein (FAP): Next generation PET radiotracers using squaramide coupled bifunctional DOTA and DATA5m chelatorsSemantic proximity Read

Fully Automated Production of [68Ga]FAPI-46 with Gallium-68 from Cyclotron Using Liquid TargetsSemantic proximity Read

Automated Production of [<sup>68</sup>Ga]Ga-desferrioxamine B on Two Different Synthesis PlatformsSemantic proximity Read

High‑yield, standardised automated radiosynthesis process for routine clinical insulinoma PET with [⁶⁸Ga]Ga‑NODAGA‑exendin‑4Semantic proximity Read

Optimized, automated and cGMP-compliant synthesis of the HER2 targeting [68Ga]Ga-ABY-025 tracerSemantic proximity Read

Preclinical evaluation of [13xLa]La-FAP-2286 as a novel theranostic agent for tumors expressing fibroblast activation proteinSemantic proximity Read

GMP-conform production of [ 68Ga ]Ga-NeoB for positron emission tomography imaging of patients with gastrointestinal stromal tumorSemantic proximity Read

Imaging Cancer-Associated Fibroblasts (CAFs) with FAPi PETSemantic proximity Read

Synthesis based on covalent capture and release (SCCR): a programmable strategy for automated preparation of protease-activatable moleculesSemantic proximity Read

Multi-Curie Production of Gallium-68 on a Biomedical Cyclotron and Automated Radiolabelling of PSMA-11 and DOTATATESemantic proximity Read

Multi-curie Production of Gallium-68 on a Biomedical Cyclotron and Automated Radiolabelling of PSMA-11 and DOTATATESemantic proximity Read