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Targeting fibroblast activation protein (FAP): Next generation PET radiotracers using squaramide coupled bifunctional DOTA and DATA5m chelators

2020-04-29

Abstract excerpt

<title>Abstract</title> <p>Background Fibroblast activation protein (FAP) is a proline selective serine protease that is overexpressed in tumor stroma and in lesions of many other diseases that are characterized by tissue remodeling. In 2014, a most potent FAP-inhibitor (referred to as UAMC1110) with low nanomolar FAP-affinity and high selectivity toward related enzymes such as prolyl oligopeptidase (PREP) and t...

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Literature Corpus work: 4edaf5a6-ed93-5237-82cb-78eedc9bea67
DOI: 10.21203/rs.3.rs-24915/v1

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