Article

DIO3 coordinates photoreceptor development timing and fate stability in human retinal organoids

2025-03-24

Abstract excerpt

The mechanisms governing the generation of neuronal subtypes at distinct times and proportions during human retinal development are poorly understood. While thyroid hormone (TH) signaling specifies cone photoreceptor subtypes, how this regulation changes over time remains unclear. To address this question, we studied the expression and function of type 3 iodothyronine deiodinase (DIO3), an enzyme that degrades TH,...

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Literature Corpus work: 775cfb7e-3675-5441-b32c-01807e2a4115
DOI: 10.1101/2025.03.20.644422

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