Article

Baicalin ameliorates behavioral and physiological deficits in <i>Gtf2i</i> -duplication mice and modulates synaptic activity in 7q11.23 Duplication Syndrome patient-derived neurons

2026-02-13

Abstract excerpt

<h4>ABSTRACT</h4> 7q11.23 Duplication Syndrome (7Dup) is a type of syndromic autism spectrum disorder caused by duplication of a typically 1.5-1.8 Mb segment in section q11.23 of chromosome 7, including 25-27 genes. Previous work has highlighted the GTF2I gene as playing a major role in the phenotype of 7Dup patients. Accordingly, mice with Gtf2i duplication ( Gtf2i +/dup ) are commonly used as an animal model...

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Literature Corpus work: 775c89fa-f175-52e8-98b3-33ccfeacc8df
DOI: 10.64898/2026.02.12.705480

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