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Contrasting behavioral and physiological effects of <i>Gtf2i</i> duplication and deletion in mouse models of the 7q11.23 Duplication and Williams-Beuren Syndromes

2025-11-14

Abstract excerpt

<h4>ABSTRACT</h4> 7q11.23 Microduplication Syndrome (7Dup) and Williams-Beuren Syndrome (WBS) are two ASD-related syndromes characterized by both common and contrasting symptoms, caused by either duplication or deletion of a 1.5-1.8 Mb segment in section q11.23 of Human chromosome 7, respectively. Notably, WBS patients show reduced social fear and are considered hyper-social, while 7Dup patients suffer from socia...

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Literature Corpus work
095e5ae8-ae01-516b-8b56-72d8c1ea9373
DOI
10.1101/2025.11.13.688274
Open publication

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