Article
Transcription Factor 2I Regulates Neuronal Development via TRPC3 in 7q11.23 Disorder Models.
Molecular neurobiology - 1 May 2019
Deurloo Marielle H S, Turlova Ekaterina, Chen Wen-Liang, Lin You Wei, Tam Elaine, Tassew Nardos G, Wu Michael, Huang Ya-Chi, Crawley Jacqueline N, Monnier Philippe P, Groffen Alexander J A, Sun Hong-Shuo, Osborne Lucy R, Feng Zhong-Ping
Abstract excerpt
Williams syndrome (WS) and 7q11.23 duplication syndrome (Dup7q11.23) are neurodevelopmental disorders caused by the deletion and duplication, respectively, of ~ 25 protein-coding genes on chromosome 7q11.23. The general transcription factor 2I (GTF2I, protein TFII-I) is one of these proteins and has been implicated in the neurodevelopmental phenotypes of WS and Dup7q11.23. Here, we investigated the effect of copy...
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