Article

signifinder enables the identification of tumor cell states and cancer expression signatures in bulk, single-cell and spatial transcriptomic data

2023-03-10

Abstract excerpt

Over the last decade, many studies and some clinical trials have proposed gene expression signatures as a valuable tool for understanding cancer mechanisms, defining subtypes, monitoring patient prognosis, and therapy efficacy. However, technical and biological concerns about reproducibility have been raised. Technical reproducibility is a major concern: we currently lack a computational implementation of the prop...

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Literature Corpus work: 775b59a9-41bf-5358-928b-79f04c36fd7f
DOI: 10.1101/2023.03.07.530940

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