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Article

Mutant MAPK7-Induced Idiopathic Scoliosis is Linked to Impaired Osteogenesis.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology - 1 Jan 2018

Zhou Taifeng, Chen Chong, Xu Caixia, Zhou Hang, Gao Bo, Su Deying, Liao Zhiheng, Li Yongyong, Yang Shulan, Su Peiqiang

Abstract excerpt

BACKGROUND/AIMS: Three rare MAPK7 variants that predispose individuals to adolescent idiopathic scoliosis have previously been identified. However, the mechanism underlying the effects of the mutations remain unknown. METHODS: Human mesenchymal stem cells (hMSCs) were isolated from both patients and healthy volunteer donors, and MAPK7 expression was detected by western blotting and real-time quantitative PCR...

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Source

Identifiers

PMID: 30032135
DOI: 10.1159/000491956

Genes

MAPK7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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