Article

Cis-regulatory elements driving motor neuron-restricted viral payload expression within the mammalian spinal cord

2024-09-04

Abstract excerpt

Spinal motor neuron (MN) dysfunction is the cause of a number of clinically significant movement disorders. Despite the recent approval of gene therapeutics targeting these MN-related disorders, there are no viral delivery mechanisms that achieve MN-restricted transgene expression. In this study, chromatin accessibility profiling of genetically defined mouse MNs was used to identify candidate cis-regulatory elemen...

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Identifiers and source

Literature Corpus work: 772467c4-1b41-5b79-972e-5d925c3a2450
DOI: 10.1101/2024.09.02.610875

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