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Article

The intronic branch point sequence is under strong evolutionary constraint in the bovine and human genome.

Communications biology - 21 Oct 2021

Kadri Naveen Kumar, Mapel Xena Marie, Pausch Hubert

Abstract excerpt

The branch point sequence is a cis-acting intronic motif required for mRNA splicing. Despite their functional importance, branch point sequences are not routinely annotated. Here we predict branch point sequences in 179,476 bovine introns and investigate their variability using a catalogue of 29.4 million variants detected in 266 cattle genomes. We localize the bovine branch point within a degenerate heptamer...

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Identifiers

PMID: 34675361
DOI: 10.1038/s42003-021-02725-7
PMCID: PMC8531310

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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