Article

Engineering the Vero Cell Lineage: Integrating Membrane, Cytoplasm, and Nucleus for a Programmable Vaccine Manufacturing Platform

2026-04-21

Abstract excerpt

Vero cells are an validated continuous substrate for human viral vaccine manufacturing. Decades of performance improvements have relied on extrinsic process optimization; however, intrinsic genomic instability, including segmental aneuploidy and dynamic chromatin rearrangements, are currently limiting the durability of engineered phenotypes under sustained viral burden and bioreactor stress. In this Perspective, w...

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Literature Corpus work: 76be03f8-c464-5812-8a89-e5be342330dd
DOI: 10.20944/preprints202604.1371.v1

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