Article

Data Independent Acquisition to Inform the Development of Targeted Proteomics Assays Using a Triple Quadrupole Mass Spectrometer

2024-05-31

Abstract excerpt

<h4>ABSTRACT</h4> Mass spectrometry based targeted proteomics methods provide sensitive and high-throughput analysis of selected proteins. To develop a targeted bottom-up proteomics assay, peptides must be evaluated as proxies for the measurement of a protein or proteoform in a biological matrix. Candidate peptide selection typically relies on predetermined biochemical properties, data from semi-stochastic sampli...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 76ae3fc9-06fb-54af-8809-d8571948e431
DOI: 10.1101/2024.05.29.596554

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Data Independent Acquisition to Inform the Development of Targeted Proteomics Assays Using a Triple Quadrupole Mass SpectrometerDOI 10.1101/2024.05.29.596554Read

Development of highly multiplex targeted proteomics assays in biofluids using the Stellar mass spectrometerSemantic proximity Read

Removing the hidden data dependency of DIA with predicted spectral librariesSemantic proximity Read

Technical advances in proteomics: new developments in data-independent acquisitionSemantic proximity Read

Paradigm shift in biomarker translation: a pipeline to generate clinical grade biomarker candidates from DIA-MS discoverySemantic proximity Read

Peptide Identification and Quantification by Gas Phase Fractionation Enables Proteomics Without Liquid ChromatographySemantic proximity Read

Narrow-window DIA: Ultra-fast quantitative analysis of comprehensive proteomes with high sequencing depthSemantic proximity Read

DPHL: A pan-human protein mass spectrometry library for robust biomarker discoverySemantic proximity Read

Picky – a simple online method designer for targeted proteomicsSemantic proximity Read

IsoPS-DIA: Dual Functionality of Absolute Targeted Quantification and Global Proteome Profiling.Semantic proximity Read

PeptiDIA: A Machine Learning Framework for Enhanced Peptide Identification in Fast-Gradient Data-Independent Acquisition ProteomicsSemantic proximity Read

Comprehensive peptide quantification for data independent acquisition mass spectrometry using chromatogram librariesSemantic proximity Read

Multicenter Evaluation of Label-Free Quantification in Human Plasma: Benchmarking with a High Dynamic Range Multispecies Sample SetSemantic proximity Read