Article

Removing the hidden data dependency of DIA with predicted spectral libraries

2019-06-26

Abstract excerpt

Data-Independent Acquisition (DIA) generates comprehensive yet complex mass spectrometric data, which imposes the use of data-dependent acquisition (DDA) libraries for deep peptide-centric detection. We here show that DIA can be redeemed from this dependency by combining predicted fragment intensities and retention times with narrow window DIA. This eliminates variation in library building and omits stochastic sam...

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Literature Corpus work: d81a63ff-7414-5f7d-be4d-9be986714793
DOI: 10.1101/681429

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