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IsoPS-DIA: Dual Functionality of Absolute Targeted Quantification and Global Proteome Profiling.

Analytical chemistry - 24 Feb 2026

Chan Hsin-Ju, Chiu Huan-Chi, Chen Li-Yu, Lai Chi-Ting, Wang Chia-Yen, Lin Shr-Uen, Yu Sung-Liang, Chen Yu-Ju

Abstract excerpt

Current gene testing reveals only the mutation status yet lacks protein expression of the actual drug target. A comprehensive evaluation requires methods that integrate the absolute quantification of mutant proteins with global profiling of downstream signaling and resistance pathways. Here, we present an isotope pair-separated data-independent acquisition (IsoPS-DIA) strategy with a dual functionality of...

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Identifiers

PMID: 41592227
DOI: 10.1021/acs.analchem.5c05651
PMCID: PMC12937053

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EGFR
KRAS

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