Article

Detection and monitoring of translocation renal cell carcinoma via plasma cell-free epigenomic profiling

2025-09-04

Abstract excerpt

<h4>ABSTRACT</h4> TFE3 translocation renal cell carcinoma (tRCC), an aggressive kidney cancer driven by TFE3 gene fusions, is frequently misdiagnosed owing to morphologic overlap with other kidney cancer subtypes. Conventional liquid biopsy assays that detect tumor DNA via somatic mutations or copy number alterations are unsuitable for tRCC, since it often lacks recurrent genetic alterations and because fusion b...

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Literature Corpus work: 76aac8e2-4805-5ad7-85f7-3bb1d3638b9b
DOI: 10.1101/2025.08.31.673338

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