Article

Genome-wide profiling of short tandem repeat somatic instability reveals associations with age, sex and brain-related traits

2025-11-15

Abstract excerpt

Short tandem repeats (STRs) are highly abundant in the human genome and their age-related somatic instability is emerging as a pivotal pathomechanism in repeat expansion disorders. Nevertheless, currently no analysis tool exists for genome-wide profiling of STR somatic instability. Here, we present searchSTR , a novel computational framework that enables accurate STR genotyping and somatic instability quantificat...

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Literature Corpus work: 76986ff1-e327-5ff3-95d4-9170d4b13f8d
DOI: 10.1101/2025.11.13.25340159

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