Article

Unravelling genome-wide mosaic microsatellite mutations at single-cell resolution

2026-02-06

Abstract excerpt

Short tandem repeats (STRs), or microsatellites, are highly mutable genomic elements that modulate gene regulations and are implicated in a range of human diseases. However, detecting mosaic STR mutations at single-cell resolution remains challenging due to both technical and biological complexities. To address this, we developed BayesMonSTR, a robust algorithm that enables accurate detection of mosaic STR mutatio...

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Literature Corpus work: 6c7c9452-ec4f-518f-95bc-b16f2fe6af06
DOI: 10.64898/2026.02.04.703915

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