Article

TCDD and kynurenine induce Parkin expression in SH-SY5Y neuroblastoma cells through different signaling pathways mediated by the aryl hydrocarbon receptor

2023-07-12

Abstract excerpt

Parkin plays an important role in regulating protein degradation and mitophagy in dopaminergic neurons. Deficiencies in Parkin expression or function result in cellular stress, degeneration, and eventual death of dopaminergic neurons, contributing to the development of Parkinson's disease. Conversely, overexpression of Parkin enhances neuronal survival. Therefore, understanding the mechanisms of Parkin regulation...

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Literature Corpus work: 76861bca-4f1a-5ebe-ba70-8120f19d59fd
DOI: 10.21203/rs.3.rs-3136537/v1

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