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Chronic and acute exposure to rotenone reveals distinct Parkinson's disease-related phenotypes in human iPSC-derived peripheral neurons.

Free radical biology & medicine - 1 Mar 2024

Saleh Mahmood Ali, Amer-Sarsour Fatima, Berant Asaf, Pasmanik-Chor Metsada, Kobo Hila, Sharabi Yehonatan, Vatine Gad D, Ashkenazi Avraham

Abstract excerpt

Peripheral autonomic nervous system (P-ANS) dysfunction is a critical non-motor phenotype of Parkinson's disease (PD). The majority of PD cases are sporadic and lack identified PD-associated genes involved. Epidemiological and animal model studies suggest an association with pesticides and other environmental toxins. However, the cellular mechanisms underlying toxin induced P-ANS dysfunctions remain unclear....

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PMID: 38246514
DOI: 10.1016/j.freeradbiomed.2024.01.016

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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