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Article

Proteomic analysis of human substantia nigra identifies novel candidates involved in <scp>P</scp>arkinson's disease pathogenesis

21 Jan 2014

Abstract excerpt

Parkinson's disease (PD) pathology spreads throughout the brain following a region-specific process predominantly affecting the substantia nigra (SN) pars compacta. SN exhibits a progressive loss of dopaminergic neurons responsible for the major cardinal motor symptoms, along with the occurrence of Lewy bodies in the surviving neurons. To gain new insights into the underlying pathogenic mechanisms in PD, we...

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PMID: 24449343
DOI: 10.1002/pmic.201300342

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