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Tracing the Origin and Evolution of the Fungal Mycophenolic Acid Biosynthesis Pathway

1 Mar 2025

Abstract excerpt

Like bacteria and plants, fungi produce a remarkable diversity of small molecules with potent activities for human health known as natural products or secondary metabolites. One such example is mycophenolic acid, a powerful immunosuppressant drug that is administered daily to millions of transplant recipients worldwide. Production of mycophenolic acid is restricted to a very limited number of filamentous fungi,...

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PMID: 40052422
DOI: 10.1093/gbe/evaf039

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