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Article

The zebrafish mutant lbk/vam6 resembles human multisystemic disorders caused by aberrant trafficking of endosomal vesicles.

Development (Cambridge, England) - 1 Jan 2008

Schonthaler Helia B, Fleisch Valerie C, Biehlmaier Oliver, Makhankov Yuri, Rinner Oliver, Bahadori Ronja, Geisler Robert, Schwarz Heinz, Neuhauss Stephan C F, Dahm Ralf

Abstract excerpt

The trafficking of intracellular vesicles is essential for a number of cellular processes and defects in this process have been implicated in a wide range of human diseases. We identify the zebrafish mutant lbk as a novel model for such disorders. lbk displays hypopigmentation of skin melanocytes and the retinal pigment epithelium (RPE), an absence of iridophore reflections, defects in internal organs (liver,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18077594
DOI: 10.1242/dev.006098

Genes

RPE
ARC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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