Article

Aging Atlas Reveals Cell-Type-Specific Regulation of Pro-longevity Strategies

2023-03-01

Abstract excerpt

Organism aging occurs at the multicellular level; however, how pro-longevity mechanisms slow down aging in different cell types remains unclear. We generated single-cell transcriptomic atlases across the lifespan of Caenorhabditis elegans under different pro-longevity conditions ( http://mengwanglab.org/atlas ). We found cell-specific, age-related changes across somatic and germ cell types and developed transcri...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 75a0607e-780a-51cc-861e-dcb50d31d6c1
DOI: 10.1101/2023.02.28.530490

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Aging Atlas Reveals Cell-Type-Specific Regulation of Pro-longevity StrategiesDOI 10.1101/2023.02.28.530490Read

The cell biology of aging.Semantic proximity Read

Age deceleration and reversal gene patterns in dauer diapauseSemantic proximity Read

Transcriptional Profiling of C. elegans Adult Cells and Tissues with Age.Semantic proximity Read

Machine learning based classification of cells into chronological stages using single-cell transcriptomicsSemantic proximity Read

Caenorhabditis elegans 2007: the premier model for the study of aging.Semantic proximity Read

Hijacking Cellular Stress Responses to Promote LifespanSemantic proximity Read

BiT age: A transcriptome-based aging clock near the theoretical limit of accuracy.Semantic proximity Read

Autophagy: A Double-Edged Sword in the Aging of <em>C. elegans</em>Semantic proximity Read

Autophagy: A Double-Edged Sword in the Aging of <em>C. elegans</em>Semantic proximity Read

Recent Progress in Regulation of Aging by Insulin/IGF-1 Signaling in Caenorhabditis elegansSemantic proximity Read

Multiple molecular pathways to longevity with opposing gene expression programs defining distinct aging strategies in Caenorhabditis elegans.Semantic proximity Read

Tissue-specific profiling of age-dependent miRNAomic changes in Caenorhabditis elegansSemantic proximity Read