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Investigating the divergence of β-lactamase PDC variants conferring various antibiotic resistance profiles in Pseudomonas aeruginosa, coupled with the molecular profiling of PDC-266

2026-07-08

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<title>Abstract</title> <p> Background <italic>Pseudomonas aeruginosa</italic> is a critical pathogen in hospital-acquired infections, with resistance primarily mediated by chromosomally encoded PDC genes. While wild-type PDCs typically hydrolyze penicillins and cephalosporins, mutations can expand their substrate spectrum. This study investigates the molecular epidemiology and biochemical characteristics of P...

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Literature Corpus work
757f9e1e-1d16-582e-bed8-274aba566856
DOI
10.21203/rs.3.rs-10024309/v1
Open publication

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Investigating the divergence of β-lactamase PDC variants conferring various antibiotic resistance profiles in Pseudomonas aeruginosa, coupled with the molecular profiling of PDC-266DOI 10.21203/rs.3.rs-10024309/v1
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