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Article

Development of carbapenem resistance in Pseudomonas aeruginosa is associated with OprD polymorphisms, particularly the amino acid substitution at codon 170.

The Journal of antimicrobial chemotherapy - 1 Sept 2017

Shu Jwu-Ching, Kuo An-Jing, Su Lin-Hui, Liu Tsui-Ping, Lee Ming-Hsun, Su I-Ning, Wu Tsu-Lan

Abstract excerpt

Objectives: Pan-susceptible Pseudomonas aeruginosa (PSPA) clinical isolates carrying an OprD with loop 7 shortening (the group-1A allele) were found to rapidly develop carbapenem resistance under continuous selection pressure. We further studied whether OprD polymorphisms are associated with the potential to develop carbapenem resistance. Methods: OprD amino acid sequences of 126 PSPA clinical isolates were...

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PMID: 28535274
DOI: 10.1093/jac/dkx158

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