High level non-carbapenemase carbapenem resistance by overlaying mutations of mexR, oprD, and ftsI in Pseudomonas aeruginosa.

doi:10.1128/spectrum.01398-24

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

High level non-carbapenemase carbapenem resistance by overlaying mutations of mexR, oprD, and ftsI in Pseudomonas aeruginosa.

Microbiology spectrum - 7 Jan 2025

Yang Yan, Li Xue, Sun Lang, Wang Xiu-Kun, Zhang You-Wen, Pang Jing, Li Guo-Qing, Hu Xin-Xin, Nie Tong-Ying, Yang Xin-Yi, Liu Jian-Hua, Brandis Gerrit, You Xue-Fu, Li Cong-Ran

Abstract excerpt

Carbapenem-resistant Pseudomonas aeruginosa (CRPA) is a global threat, but the mechanism of non-carbapenemase carbapenem resistance is still unclear. In the current study, we investigated the contributions of point mutations in mexR, oprD, and ftsI to carbapenem resistance in P. aeruginosa during in vivo evolution studies with consecutive clinical isolates. Real-time qPCR and Electrophoretic Mobility Shift Assay...

Read the complete abstract on PubMed