Article

Haldane’s rule in the placenta: sex-biased misregulation of the <i>Kcnq1</i> imprinting cluster in hybrid mice

2020-05-07

Abstract excerpt

<h4>ABSTRACT</h4> Mammalian hybrids often show striking asymmetries in their phenotypes both between reciprocal crosses, and between sexes in accordance with Haldane’s rule. Hybrid inviability is associated with parent-of-origin placental growth abnormalities for which misregulation of imprinted genes is a strong candidate mechanism. However, direct evidence for the involvement of abnormal imprinting and the mech...

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Literature Corpus work: 755a2fa0-98f3-5727-9746-954784f9f8a8
DOI: 10.1101/2020.05.07.082248

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Haldane’s rule in the placenta: sex-biased misregulation of the <i>Kcnq1</i> imprinting cluster in hybrid miceDOI 10.1101/2020.05.07.082248Read

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