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Article

The Parental Non-Equivalence of Imprinting Control Regions during Mammalian Development and Evolution

18 Nov 2010

Abstract excerpt

In mammals, imprinted gene expression results from the sex-specific methylation of imprinted control regions (ICRs) in the parental germlines. Imprinting is linked to therian reproduction, that is, the placenta and imprinting emerged at roughly the same time and potentially co-evolved. We assessed the transcriptome-wide and ontology effect of maternally versus paternally methylated ICRs at the developmental stage...

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PMID: 21124941
DOI: 10.1371/journal.pgen.1001214

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