Article
An unusual Zn-finger/FH2 domain protein controls a left/right asymmetric neuronal fate decision in C. elegans.
Development (Cambridge, England) - 1 Sept 2006
Johnston Robert J, Copeland John W, Fasnacht Marc, Etchberger John F, Liu Jun, Honig Barry, Hobert Oliver
Abstract excerpt
Gene regulatory networks that control the terminally differentiated state of a cell are, by and large, only superficially understood. In a mutant screen aimed at identifying regulators of gene batteries that define the differentiated state of two left/right asymmetric C. elegans gustatory neurons, ASEL and ASER, we have isolated a mutant, fozi-1, with a novel mixed-fate phenotype, characterized by de-repression...
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