Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

KDM4C, a H3K9me3 Histone Demethylase, is Involved in the Maintenance of Human ESCC-Initiating Cells by Epigenetically Enhancing SOX2 Expression

19 Sept 2016

Abstract excerpt

Our studies investigating the existence of tumor-initiating cell (TIC) populations in human esophageal squamous cell carcinoma (ESCC) had identified a subpopulation of cells isolated from ESCC patient-derived tumor specimens marked by an ALDHbri+ phenotype bear stem cell-like features. Importantly, KDM4C, a histone demethylase was enhanced in ALDHbri+ subpopulation, suggesting that strategies interfering with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Cells and Metastasis
Share to Cancer-related gene regulation
Share to Epigenetics and DNA Methylation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 27742014
DOI: 10.1016/j.neo.2016.08.005

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

KDM4C, a H3K9me3 Histone Demethylase, is Involved in the Maintenance of Human ESCC-Initiating Cells by Epigenetically Enhancing SOX2 ExpressionPMID 27742014Read ↗

Defeating EpCAM+ liver cancer stem cells by targeting chromatin remodeling enzyme CHD4 in human hepatocellular carcinomaSemantic proximity Read ↗

Histone H3K27me3 demethylases KDM6A and KDM6B modulate definitive endoderm differentiation from human ESCs by regulating WNT signaling pathwaySemantic proximity Read ↗

KDM6B promotes ESCC cell proliferation and metastasis by facilitating C/EBPβ transcriptionSemantic proximity Read ↗

MAFB promotes the malignant phenotypes by IGFBP6 in esophageal squamous cell carcinomas.Semantic proximity Read ↗

RCOR2 Is a Subunit of the LSD1 Complex That Regulates ESC Property and Substitutes for SOX2 in Reprogramming Somatic Cells to PluripotencySemantic proximity Read ↗

Mutations inhibiting KDM4B drive ALT activation in ATRX-mutated glioblastomas.Semantic proximity Read ↗

DDB2 represses ovarian cancer cell dedifferentiation by suppressing ALDH1A1Semantic proximity Read ↗

Deciphering the Epigenetic Role of KDM4A in Pancreatic β-like Cell Differentiation from iPSCsSemantic proximity Read ↗

Targeting of cancer stem cells by inhibitors of DNA and histone methylationSemantic proximity Read ↗

DNMT3A promotes the proliferation and metastasis of esophageal squamous cell carcinoma via upregulating HDAC9Semantic proximity Read ↗

Histone Demethylases KDM4B and KDM6B Promotes Osteogenic Differentiation of Human MSCsSemantic proximity Read ↗

MBIP promotes ESCC metastasis by activating MAPK pathwaySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.