Article

COX6B1 secures a redox-sensitive step in early cytochrome <i>c</i> oxidase assembly

2025-03-26

Abstract excerpt

COX6B1 is a nuclear-encoded subunit of the human mitochondrial cytochrome c oxidase (cIV) located in its intermembrane space-facing region. The relevance of COX6B1 in mitochondrial physiopathology was highlighted by the missense pathogenic variants associated with cIV deficiency. Despite the assigned COX6B1 role as a late incorporation subunit, the COX6B1 human cell line knock-out (KO) exhibited a total loss of cI...

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Literature Corpus work: 9431cab7-ad0d-5b22-b488-cd947048f6c0
DOI: 10.1101/2025.03.25.645161

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