Article

Photostimulation of Locus Coeruleus CA1 catecholaminergic terminals reversed spatial memory impairment in an Alzheimer's disease mouse model.

2025-01-22

Abstract excerpt

<title>Abstract</title> <p><bold>Rationale</bold> One of the earliest changes associated with Alzheimer's disease (AD) is the loss of catecholaminergic terminals in the cortex and hippocampus originating from the Locus Coeruleus (LC). This decline leads to reduced catecholaminergic neurotransmitters in the hippocampus, affecting synaptic plasticity and spatial memory. However, it is unclear whether restoring cate...

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Literature Corpus work: 73f52401-3ea1-5bbd-9963-df7f432ffb44
DOI: 10.21203/rs.3.rs-5868268/v1

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