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3D culture of pancreatic cancer cells <i>in vitro</i> recapitulates an aberrant mitochondrial oxidative phosphorylation genotype observed <i>in vivo</i>

2024-03-12

Abstract excerpt

The treatment of many aggressive cancers remains a significant unmet medical need. An aberrant dependence of tumors on mitochondrial oxidative phosphorylation pathways has been well characterized in mediating the progression of pancreatic cancers, as well as some other malignancies. However, the discovery and development of new therapeutic strategies targeting or manipulating this pathway in pancreatic tumors has...

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Literature Corpus work
59afffdc-f7e5-5a0e-9e1f-cc7f781e35b6
DOI
10.1101/2024.03.08.583569
Open publication

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3D culture of pancreatic cancer cells <i>in vitro</i> recapitulates an aberrant mitochondrial oxidative phosphorylation genotype observed <i>in vivo</i>DOI 10.1101/2024.03.08.583569
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