Article

Sertoli cell-only phenotype and scRNA-seq reveal hnRNPU as a regulator required for spermatogonial stem cell pool establishment in mice

2022-11-11

Abstract excerpt

<title>Abstract</title> <p>The continuous regeneration of spermatogonial stem cells (SSCs) underpins spermatogenesis and lifelong male fertility; however, little is known about the developmental origins of the SSC pool. Here, we document that heterogeneous nuclear ribonucleoprotein U (hnRNPU) is essential for establishing the SSC pool. In male mice, conditional loss of hnRNPU in prospermatogonia (ProSG) arrests s...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 73ca6de4-b688-54e5-a904-2fe9dee19924
DOI: 10.21203/rs.3.rs-2254778/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Sertoli cell-only phenotype and scRNA-seq reveal hnRNPU as a regulator required for spermatogonial stem cell pool establishment in miceDOI 10.21203/rs.3.rs-2254778/v1Read

SRSF10 is essential for progenitor spermatogonia expansion by regulating alternative splicingSemantic proximity Read

Azoospermia phenotype and scRNA-seq reveal hnRNPK as a factor essential for male germ cell development in mice.Semantic proximity Read

Single-cell RNA-seq unravels alterations of the human spermatogonial stem cell compartment in patients with impaired spermatogenesisSemantic proximity Read

Human spermatogonial stem cells and their niche in male (in)fertility: novel concepts from single-cell RNA-sequencingSemantic proximity Read

Sertoli cell-only phenotype and scRNA-seq define PRAMEF12 as a factor essential for spermatogenesis in mice.Semantic proximity Read

HnRNPK is essential for Sertoli cells development and male fertility in miceSemantic proximity Read

The Mammalian Spermatogenesis Single-Cell Transcriptome, from Spermatogonial Stem Cells to SpermatidsSemantic proximity Read

Transcriptomic and epigenomic profiling of young and aged spermatogonial stem cells reveals molecular targets regulating differentiationSemantic proximity Read

miRNA Signature in Mouse Spermatogonial Stem Cells Revealed by High-Throughput SequencingSemantic proximity Read

Transcriptomic and epigenomic profiling of young and aged spermatogonial stem cells reveals molecular targets regulating differentiationSemantic proximity Read

The adult human testis transcriptional cell atlasSemantic proximity Read

Single-cell RNA sequencing of human, macaque, and mouse testes uncovers conserved and divergent features of mammalian spermatogenesisSemantic proximity Read