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Article

Sertoli cell-only phenotype and scRNA-seq define PRAMEF12 as a factor essential for spermatogenesis in mice.

Nature communications - 15 Nov 2019

Wang Zhengpin, Xu Xiaojiang, Li Jian-Liang, Palmer Cameron, Maric Dragan, Dean Jurrien

Abstract excerpt

Spermatogonial stem cells (SSCs) have the dual capacity to self-renew and differentiate into progenitor spermatogonia that develop into mature spermatozoa. Here, we document that preferentially expressed antigen of melanoma family member 12 (PRAMEF12) plays a key role in maintenance of the spermatogenic lineage. In male mice, genetic ablation of Pramef12 arrests spermatogenesis and results in sterility which can...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 31729367
DOI: 10.1038/s41467-019-13193-3
PMCID: PMC6858368

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