Article

Microvascular pathology of proteotoxic endothelial signature characterizes Progressive Supranuclear Palsy

2026-07-21

Abstract excerpt

Cerebrovascular pathology is increasingly implicated in neurodegenerative diseases, yet its pathomechanistic contribution remains poorly defined. Building on prior evidence of dysregulated iron and oxygen homeostasis in early-affected brain regions of progressive supranuclear palsy (PSP), we hypothesized that brain microvascular alterations may play an etiological role in select neurodegenerative proteinopathies....

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Literature Corpus work: 73c30288-fc55-54e7-8172-d22b2e69aab7
DOI: 10.64898/2026.07.16.738175

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