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Article

Activation of unfolded protein response pathways promotes keratinocyte differentiation and ameliorates psoriasis phenotypes.

Cell stress & chaperones - 1 May 2026

Zhang Zhibao, Tan Mingyi, Liu Xin, Wang Wenhua, Chen Xiang, Peng Cong, Zhao Shuang, Wu Lisha

Abstract excerpt

Psoriasis is a chronic inflammatory skin disorder characterized by abnormal keratinocyte (KC) differentiation and proliferation, along with infiltration of various immune cells into the skin. Both internal and external perturbations can disrupt endoplasmic reticulum (ER) homeostasis, leading to ER stress and activation of the unfolded protein response (UPR) pathways. Although the UPR is known to participate in...

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Identifiers

PMID: 41765076
DOI: 10.1016/j.cstres.2026.100163
PMCID: PMC12997330

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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