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Serum Exosomal Multi-Omic Signatures Stratify Glucose Tolerance in Cystic Fibrosis and Reveal Partial Therapeutic Reprogramming by CFTR Modulators

2025-07-08

Abstract excerpt

<h4>ABSTRACT</h4> Cystic fibrosis-related diabetes (CFRD) affects up to 60% of adults with CF and contributes to poorer clinical outcomes, including accelerated lung decline and increased mortality. CFRD is often diagnosed late, with limited mechanistic insight and few tools for early detection. We profiled serum-derived exosomes from 186 individuals, 173 with CF, across two independent cohorts (Australia and Den...

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Literature Corpus work
73c0824b-aba5-5e91-983f-668c5102fe43
DOI
10.1101/2025.07.07.25331056
Open publication

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