Article
Genetic Modifiers of Cystic Fibrosis-Related Diabetes Have Extensive Overlap With Type 2 Diabetes and Related Traits.
The Journal of clinical endocrinology and metabolism - 1 May 2020
Aksit Melis A, Pace Rhonda G, Vecchio-Pagán Briana, Ling Hua, Rommens Johanna M, Boelle Pierre-Yves, Guillot Loic, Raraigh Karen S, Pugh Elizabeth, Zhang Peng, Strug Lisa J, Drumm Mitch L, Knowles Michael R, Cutting Garry R, Corvol Harriet, Blackman Scott M
Abstract excerpt
CONTEXT: Individuals with cystic fibrosis (CF) develop a distinct form of diabetes characterized by β-cell dysfunction and islet amyloid accumulation similar to type 2 diabetes (T2D), but generally have normal insulin sensitivity. CF-related diabetes (CFRD) risk is determined by both CFTR, the gene responsible for CF, and other genetic variants. OBJECTIVE: To identify genetic modifiers of CFRD and determine the...
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