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Article

T-cell receptor-β V and J usage, in combination with particular HLA class I and class II alleles, correlates with cancer survival patterns.

Cancer immunology, immunotherapy : CII - 1 Jun 2018

Callahan Blake M, Yavorski John M, Tu Yaping N, Tong Wei Lue, Kinskey Jacob C, Clark Kendall R, Fawcett Timothy J, Blanck George

Abstract excerpt

Class I and class II HLA proteins, respectively, have been associated with subsets of V(D)J usage resulting from recombination of the T-cell receptor (TCR) genes. Additionally, particular HLA alleles, in combination with dominant TCR V(D)J recombinations, have been associated with several autoimmune diseases. The recovery of TCR recombination reads from tumor specimen exome files has allowed rapid and extensive...

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Identifiers

PMID: 29508024
DOI: 10.1007/s00262-018-2139-7
PMCID: PMC11028132

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