Trans-ancestry analysis reveals genetic and nongenetic associations with COVID-19 susceptibility and severity.

doi:10.1038/s41588-021-00854-7

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Article

Trans-ancestry analysis reveals genetic and nongenetic associations with COVID-19 susceptibility and severity.

Nature genetics - 1 Jun 2021

Shelton Janie F, Shastri Anjali J, Ye Chelsea, Weldon Catherine H, Filshtein-Sonmez Teresa, Coker Daniella, Symons Antony, Esparza-Gordillo Jorge, Aslibekyan Stella, Auton Adam

Abstract excerpt

COVID-19 presents with a wide range of severity, from asymptomatic in some individuals to fatal in others. Based on a study of 1,051,032 23andMe research participants, we report genetic and nongenetic associations with testing positive for SARS-CoV-2, respiratory symptoms and hospitalization. Using trans-ancestry genome-wide association studies, we identified a strong association between blood type and COVID-19...

Topics

ABO Blood-Group System
Blood Grouping and Crossmatching
COVID-19
Chromosomes, Human, Pair 3
Databases, Genetic
Disease Susceptibility
Female
Galactosyltransferases
Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genome-Wide Association Study

Hospitalization

Humans

Male

Middle Aged

Patient Acuity

Racial Groups

Risk Factors

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Open in PubMed

Identifiers

PMID: 33888907
DOI: 10.1038/s41588-021-00854-7

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