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Proximal telomeric decompaction due to telomere shortening drives FOXC1-dependent myocardial senescence

3 Apr 2024

Abstract excerpt

Telomeres, TTAGGGn DNA repeat sequences located at the ends of eukaryotic chromosomes, play a pivotal role in aging and are targets of DNA damage response. Although we and others have demonstrated presence of short telomeres in genetic cardiomyopathic and heart failure cardiomyocytes, little is known about the role of telomere lengths in cardiomyocyte. Here, we demonstrate that in heart failure patient...

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PMID: 38634789
DOI: 10.1093/nar/gkae274

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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