Article
Telomere shortening is a hallmark of genetic cardiomyopathies.
Proceedings of the National Academy of Sciences of the United States of America - 11 Sept 2018
Chang Alex C Y, Chang Andrew C H, Kirillova Anna, Sasagawa Koki, Su Willis, Weber Gerhard, Lin Jue, Termglinchan Vittavat, Karakikes Ioannis, Seeger Timon, Dainis Alexandra M, Hinson John T, Seidman Jonathan, Seidman Christine E, Day John W, Ashley Euan, Wu Joseph C, Blau Helen M
Abstract excerpt
This study demonstrates that significantly shortened telomeres are a hallmark of cardiomyocytes (CMs) from individuals with end-stage hypertrophic cardiomyopathy (HCM) or dilated cardiomyopathy (DCM) as a result of heritable defects in cardiac proteins critical to contractile function. Positioned at the ends of chromosomes, telomeres are DNA repeats that serve as protective caps that shorten with each cell...
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