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Article

Analysis of RBP expression and binding sites identifies PTBP1 as a regulator of CD19 expression in B-ALL.

Oncoimmunology - 1 Jan 2023

Ziegler Nicole, Cortés-López Mariela, Alt Francesca, Sprang Maximilian, Ustjanzew Arsenij, Lehmann Nadine, El Malki Khalifa, Wingerter Arthur, Russo Alexandra, Beck Olaf, Attig Sebastian, Roth Lea, König Julian, Paret Claudia, Faber Jörg

Abstract excerpt

Despite massive improvements in the treatment of B-ALL through CART-19 immunotherapy, a large number of patients suffer a relapse due to loss of the targeted epitope. Mutations in the CD19 locus and aberrant splicing events are known to account for the absence of surface antigen. However, early molecular determinants suggesting therapy resistance as well as the time point when first signs of epitope loss appear...

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Share to Antigens, CD19
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Heterogeneous-Nuclear Ribonucleoproteins

Share to Leukemia, B-Cell

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Share to Polypyrimidine Tract-Binding Protein

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Source

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Identifiers

PMID: 36875548
DOI: 10.1080/2162402X.2023.2184143
PMCID: PMC9980455

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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