Article

Effect of a Soluble Guanylate Cyclase Stimulator on the Purinergic Pathway in an Animal Model of Emphysema Induced by Cigarette Smoke

2022-05-17

Abstract excerpt

Purinergic and nitric oxide (NO) signaling pathways appear to be involved in the development of emphysema and vascular remodeling of chronic obstructive pulmonary disease (COPD). In an animal model, we evaluate the gene and protein expression of ENTPD1 /CD39 and NT5E /CD73, and the effect on this expression of a guanylate cyclase (GC) stimulator. Forty-two guinea pigs underwent sham exposure (SHAM) or cigarette sm...

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Literature Corpus work: 73187b22-193d-51b0-9c3e-4accf7a6ef72
DOI: 10.21203/rs.3.rs-1532805/v1

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