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Article

High prevalence of unusual KRAS, NRAS, and BRAF mutations in POLE-hypermutated colorectal cancers.

Molecular oncology - 1 Sept 2022

Favre Loetitia, Cohen Justine, Calderaro Julien, Pécriaux Adrien, Nguyen Cong-Trung, Bourgoin Rémi, Larnaudie Laura, Dupuy Aurélie, Ollier Marie, Lechapt Emmanuèle, Sloma Ivan, Tournigand Christophe, Rousseau Benoit, Pujals Anaïs

Abstract excerpt

Exonucleasic domain POLE (edPOLE) mutations, which are responsible for a hypermutated tumor phenotype, occur in 1-2% of colorectal cancer (CRC) cases. These alterations represent an emerging biomarker for response to immune checkpoint blockade. This study aimed to assess the molecular characteristics of edPOLE-mutated tumors to facilitate patient screening. Based on opensource data analysis, we compared the...

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Identifiers

PMID: 35624529
DOI: 10.1002/1878-0261.13257
PMCID: PMC9441000

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High prevalence of unusual KRAS, NRAS, and BRAF mutations in POLE-hypermutated colorectal cancers.PMID 35624529Read ↗

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