Article

Hypothalamic estrogen receptor alpha mediates key side effects of tamoxifen therapy in mice

2020-09-21

Abstract excerpt

Adjuvant tamoxifen therapy for invasive breast cancer improves patient survival. Unfortunately, long-term treatment comes with side effects that impact health and quality of life, including hot flashes, changes in bone density, and fatigue. Partly due to a lack of proven animal models, the tissues and cell types that mediate these negative side effects are largely unknown. Here we show that mice undergoing a 28-da...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7303fc01-fcee-5a10-821a-82c841a1485c
DOI: 10.1101/2020.09.21.307124

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Hypothalamic estrogen receptor alpha mediates key side effects of tamoxifen therapy in miceDOI 10.1101/2020.09.21.307124Read

Progressive hypothalamic neuroinflammation after ovariectomy in mice parallels age-related transcriptomic changes in the female human hypothalamusSemantic proximity Read

Estrogen receptor alpha regulates alcohol craving in females: convergent evidence from mouse models and human geneticsSemantic proximity Read

Regulation of neural gene expression by estrogen receptor alphaSemantic proximity Read

Estrogen Drives Melanocortin Neurons To Increase Spontaneous Activity and Reduce Sedentary BehaviorSemantic proximity Read

Evaluation of hypothalamic gene expression in mice divergently selected for heat loss.Semantic proximity Read

Estrogen receptor inhibition enhances cold-induced adipocyte beiging and glucose sensitivitySemantic proximity Read

Clinical and biomarker predictors of side effects from tamoxifen.Semantic proximity Read

The testosterone-dependent and independent transcriptional networks in the hypothalamus of Gpr54 and Kiss1 knockout male mice are not fully equivalent.Semantic proximity Read

Silencing of estrogen receptor α in the ventromedial nucleus of hypothalamus leads to metabolic syndromeSemantic proximity Read

The human forebrain has discrete estrogen receptor α messenger RNA expression: high levels in the amygdaloid complexSemantic proximity Read

Molecular interactions underpinning the phenotype of hibernation in mammalsSemantic proximity Read

Energy restriction lowers the expression of genes linked to inflammation, the cytoskeleton, the extracellular matrix, and angiogenesis in mouse adipose tissue.Semantic proximity Read