A germline shortcut in protein language model retrieval of adaptive immune receptors

Abstract excerpt

Protein language models (PLMs) are increasingly used to represent adaptive immune receptors; however, their advantages over classical alignment-based methods remain unclear. We benchmarked the ESM2 family, ESM-C, antibody-, and TCR-specific PLMs against sequence-alignment methods across four B-cell and T-cell receptor databases using CDR3, clonotype, paratope, and full variable domain representations. At the CDR3...

Topics

Open a Topic to create a Post that cites this publication.

• Amino Acid Sequence
• Antibodies
• Computational Biology
• Germ-Line Mutation
• Monoclonal and Polyclonal Antibodies Research
• Mutation
• RNA and protein synthesis mechanisms
• vaccines and immunoinformatics approaches

Identifiers and source

Literature Corpus work

72d1b9f6-c69f-5fcd-9b20-66094a25edf3

DOI

10.64898/2026.07.21.739963