Article

Predicting Immune Escape with Pretrained Protein Language Model Embeddings

2022-12-02

Abstract excerpt

Assessing the severity of new pathogenic variants requires an understanding of which mutations enable escape of the human immune response. Even single point mutations to an antigen can cause immune escape and infection by disrupting antibody binding. Recent work has modeled the effect of single point mutations on proteins by leveraging the information contained in large-scale, pretrained protein language models (P...

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Literature Corpus work: 3ca818aa-31ca-5bc2-9b11-9573c7d38aa1
DOI: 10.1101/2022.11.30.518466

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