Article

Lysophosphatidic acid (LPA)-antibody (504B3) validation by free-solution assay and interferometry identifies off-target binding

2020-10-05

Abstract excerpt

Antibody specificity and sensitivity is required in basic and clinical research for ensuring scientific rigor and reproducibility, while off-target cross-reactivity could generate erroneous conclusions. Lysophosphatidic acid (LPA) is a bioactive lipid being targeted clinically by antibody strategies. Here, we reexamined binding properties of a commercially available monoclonal antibody (504B3) reported as specific...

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Literature Corpus work: 72ae80a6-f2a3-595e-b37c-febf8e37fdab
DOI: 10.1101/2020.10.05.327122

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